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The Food and Drug Administration, FDA, has approved the drug Vivitrol to the treatment of opioid dependence in accordance with a news release by them on 10-12-2010.

Using two separate drugs to shed pounds can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with fat loss and the individuals who go through it you need to err along the side of caution and allow the FDA do its job and demand some study be done so your public recognizes the side effects and hazards of the medications before we take them. Keep in mind that drug companies have been in business to generate income and that they would say everything to keep people on their medications.

Researchers discovered that participants investing in this drug for the year, dropped excess weight within one month and have kept the load off throughout the 56 weeks in the study. Contrave is often a combination with the drugs naltrexone and bupropion, which generally seems to reflect a brand new trend of weight-loss drugs which might be made up of several active ingredient, that might make them more potent and safer.

Combo-pilling could be the newest fad or also the newest into the future under scrutiny and so it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular will be the fact that as of right now there are not any long term prescription slimming capsules that have been authorized by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be licensed by the FDA.

Seizures really are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug can also raise blood pressure level and heartrate, and must not be used in people with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise hypertension and heartrate and must stop used in patients with uncontrolled high hypertension, along with by a person with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients to the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

Suboxone includes two drugs; buprenorphine and naloxone. The naloxone is irrelevant in the event the addict uses the medication properly, but in the event the tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone is utilized correctly, the naloxone is destroyed inside liver shortly after uptake in the intestines and has no therapeutic effect. Buprenorphine will be the active substance; it is absorbed beneath the tongue (and through the mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I have used this formulation when the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I also have treated addicts who have had gastric bypass, in which the first section of the intestine is bypassed as well as the stomach contents empty in a more distal part of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the method with normal anatomy the location where the drug is taken up by the duodenum and transferred right to the liver with the portal vein, where it's quickly and completely destroyed. After gastric bypass naloxone can be taken on by portions of the intestine which are not served through the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.